Characteristics of patients admitted to the ICU with Kaposi sarcoma herpesvirus-associated diseases.

ABSTRACT:

Objective

There are four conditions caused by Kaposi sarcoma herpesvirus (KSHV): Kaposi sarcoma, KSHV-associated multicentric Castleman disease (MCD), primary effusion lymphoma (PEL), and KSHV inflammatory cytokine syndrome (KICS). These KSHV-associated disorders (KADs) often occur in people with HIV and can lead to multiorgan dysfunction requiring admission to the ICU. However, little is known about patient outcomes in this setting.

Methods

A retrospective study of patients with KADs admitted to the ICU between 2010 and 2021 was conducted, examining KAD admission diagnoses, HIV characteristics, selected cytokine profiles, and ICU interventions. Primary outcomes were 60-day and median overall survival from ICU admission to death from any cause.

Results

Forty-seven pat

SUBMITTER: Hansen ME 

PROVIDER: S-EPMC9617765 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature