Guanidinium and amide CEST mapping of human brain by high spectral resolution CEST at 3 T.

ABSTRACT:

Purpose

To extract guanidinium (Guan) and amide CEST on the human brain at 3 T MRI with the high spectral resolution (HSR) CEST combined with the polynomial Lorentzian line-shape fitting (PLOF).

Methods

Continuous wave (cw) turbo spin-echo (TSE) CEST was implemented to obtain the optimum saturation parameters. Both Guan and amide CEST peaks were extracted and quantified using the PLOF method. The NMR spectra on the egg white phantoms were acquired to reveal the fitting range and the contributions to the amide and GuanCEST. Two types of CEST approaches, including cw gradient- and spin-echo (cwGRASE) and steady state EPI (ssEPI), were implemented to acquire multi-slice HSR-CEST.

Results

GuanCEST can be extracted with the PLOF method at 3 T, and the optimum B1=0.6μT$$ {\

SUBMITTER: Wang K 

PROVIDER: S-EPMC9617768 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature