High-resolution dynamic susceptibility contrast perfusion imaging using higher-order temporal smoothness regularization.

ABSTRACT:

Purpose

To improve image quality and resolution of dynamic susceptibility contrast perfusion weighted imaging (DSC-PWI) by developing acquisition and reconstruction methods exploiting the temporal regularity property of DSC-PWI signal.

Theory and methods

A novel regularized reconstruction is proposed that recovers DSC-PWI series from interleaved segmented spiral k-space acquisition using higher order temporal smoothness (HOTS) properties of the DSC-PWI signal. The HOTS regularization is designed to tackle representational insufficiency of the standard first-order temporal regularizations for supporting higher accelerations. The higher accelerations allow for k-space coverage with shorter spiral interleaves resulting in improved acquisition point spread function, and acquisit

SUBMITTER: Velikina JV 

PROVIDER: S-EPMC9617779 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature