Gut-innervating nociceptors regulate the intestinal microbiota to promote tissue protection.

ABSTRACT: Nociceptive pain is a hallmark of many chronic inflammatory conditions including inflammatory bowel diseases (IBDs); however, whether pain-sensing neurons influence intestinal inflammation remains poorly defined. Employing chemogenetic silencing, adenoviral-mediated colon-specific silencing, and pharmacological ablation of TRPV1⁺ nociceptors, we observed more severe inflammation and defective tissue-protective reparative processes in a murine model of intestinal damage and inflammation. Disrupted nociception led to significant alterations in the intestinal microbiota and a transmissible dysbiosis, while mono-colonization of germ-free mice with Gram⁺Clostridium spp. promoted intestinal tissue protection through a nociceptor-dependent pathway. Mechanistically, disruptio

SUBMITTER: Zhang W 

PROVIDER: S-EPMC9617796 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature