Further characterization of tryptophan metabolism and its dysregulation in fibroids.

ABSTRACT:

Objective

To determine the expression of enzymes in tryptophan (Trp) catabolism in fibroids and matched myometrium and determine the effects of race and mediator complex subunit 12 gene (MED12) mutation on their expression.

Design

Experimental laboratory study.

Setting

Academic research laboratory.

Patient(s)

Women of reproductive age who underwent hysterectomy while on no hormonal medications before surgery.

Intervention(s)

Fibroids and matched myometrium were obtained from patients who underwent hysterectomy from different race or ethnic groups.

Main outcome measure(s)

The expression of enzymes in the Trp catabolic pathway, tryptophan transporters, and the cytochrome P450 1B1 gene (CYP1B1) in the fibroids and matched myometrium of women from dif

SUBMITTER: Chuang TD 

PROVIDER: S-EPMC9617805 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature