Impaired dynamic functional brain properties and their relationship to symptoms in never treated first-episode patients with schizophrenia.

ABSTRACT: Studies of dynamic functional connectivity (dFC) and topology can provide novel insights into the neurophysiology of brain dysfunction in schizophrenia and its relation to core symptoms of psychosis. Limited investigations of these disturbances have been conducted with never-treated first-episode patients to avoid the confounds of treatment or chronic illness. Therefore, we recruited 95 acutely ill, first-episode, never-treated patients with schizophrenia and examined brain dFC patterns relative to healthy controls using resting-state functional magnetic resonance imaging and a sliding-window approach. We compared the dynamic attributes at the group level and found patients spent more time in a hypoconnected state and correspondingly less time in a hyperconnected state. Patients demonstrat

SUBMITTER: You W 

PROVIDER: S-EPMC9617869 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature