Prognostic associations of cortical gyrification in minimally medicated schizophrenia in an early intervention setting.

ABSTRACT: The aberration in cortical gyrification seen in schizophrenia likely originates in the earliest phase of life, as gyrification begins in utero and reaches its peak in infancy. However, emerging observations have indicated a later reduction in gyrification, especially in early adulthood, may also occur in schizophrenia. At present, it is unclear whether the baseline and later gyrification reduction has any prognostic importance in schizophrenia. We address this question in a longitudinal design in patients minimally medicated at inception. About 108 minimally medicated (duration of medication = <14 days of antipsychotics) patients and 106 healthy controls underwent structural magnetic resonance imaging, with 34 patients being selectively re-scanned when clinically stable following antipsych

SUBMITTER: Yunzhi P 

PROVIDER: S-EPMC9617870 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature