LINC00589-dominated ceRNA networks regulate multiple chemoresistance and cancer stem cell-like properties in HER2⁺ breast cancer.

ABSTRACT: Resistance to human epidermal growth factor receptor 2 (HER2)-targeted therapy (trastuzumab), cancer stem cell (CSC)-like properties and multiple chemoresistance often concur and intersect in breast cancer, but molecular links that may serve as effective therapeutic targets remain largely unknown. Here, we identified the long noncoding RNA, LINC00589 as a key regulatory node for concurrent intervention of these processes in breast cancer cells in vitro and in vivo. We demonstrated that the expression of LINC00589 is clinically valuable as an independent prognostic factor for discriminating trastuzumab responders. Mechanistically, LINC00589 serves as a ceRNA platform that simultaneously sponges miR-100 and miR-452 and relieves their repression of tumor suppressors, including discs large hom

SUBMITTER: Bai W 

PROVIDER: S-EPMC9617889 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature