Proteo-genomic characterization of virus-associated liver cancers reveals potential subtypes and therapeutic targets.

ABSTRACT: Primary liver cancer is a heterogeneous disease in terms of its etiology, histology, and therapeutic response. Concurrent proteomic and genomic characterization of a large set of clinical liver cancer samples can help elucidate the molecular basis of heterogeneity and thus serve as a valuable resource for personalized liver cancer treatment. In this study, we perform proteomic profiling of ~300 proteins on 259 primary liver cancer tissues with reverse-phase protein arrays, mutational analysis using whole genome sequencing and transcriptional analysis with RNA-Seq. Patients are of Japanese ethnic background and mainly HBV or HCV positive, providing insight into this important liver cancer subtype. Unsupervised classification of tumors based on protein expression profiles reveal three proteo

SUBMITTER: Fujita M 

PROVIDER: S-EPMC9617926 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature