Clinical relevance of CERK and SPHK1 in breast cancer and their association with metastasis and drug resistance.

ABSTRACT: Despite numerous reports on the altered sphingolipids metabolism in human cancers, their clinical significance in breast cancer remains obscure. Previously, we identified the high levels of sphingolipids, ceramide phosphates and sphingosine phosphates, and the genes involved in their synthesis, CERK and SPHK1, in breast cancer patients. The present study aimed to determine the correlations of CERK and SPHK1 with clinical outcomes as well as metastasis and drug resistance markers. Both local and TCGA cohorts were analysed. High-confidence regulatory interaction network was constructed to find association of target genes with metastasis and drug resistance. Furthermore, correlations of CERK and SPHK1 with selected metastasis and drug resistance markers were validated in both cohorts. Overexp

SUBMITTER: Bhadwal P 

PROVIDER: S-EPMC9617946 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature