Photoacoustic image-guided biomimetic nanoparticles targeting rheumatoid arthritis.

ABSTRACT: The high level of reactive oxygen species (ROS) in the rheumatoid arthritis (RA) microenvironment (RAM) and its persistent inflammatory nature can promote damage to joints, bones, and the synovium. Targeting strategies that integrate effective RAM regulation with imaging-based monitoring could lead to improvements in the diagnosis and treatment of RA. Here, we report the combined use of small interfering RNAs (siRNAs^T/I) and Prussian blue nanoparticles (PBNPs) to silence the expression of proinflammatory cytokines TNF-α/IL-6 and scavenge the ROS associated with RAM. To enhance the in vitro and in vivo biological stability, biocompatibility, and targeting capability of the siRNAs^T/I and PBNPs, macrophage membrane vesicles were used to prepare biomimetic nanoparticles,

SUBMITTER: Chen J 

PROVIDER: S-EPMC9618076 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature