Treatment with an antigen-specific dual microparticle system reverses advanced multiple sclerosis in mice.

ABSTRACT: Antigen-specific therapies hold promise for treating autoimmune diseases such as multiple sclerosis while avoiding the deleterious side effects of systemic immune suppression due to delivering the disease-specific antigen as part of the treatment. In this study, an antigen-specific dual-sized microparticle (dMP) treatment reversed hind limb paralysis when administered in mice with advanced experimental autoimmune encephalomyelitis (EAE). Treatment reduced central nervous system (CNS) immune cell infiltration, demyelination, and inflammatory cytokine levels. Mechanistic insights using single-cell RNA sequencing showed that treatment impacted the MHC II antigen presentation pathway in dendritic cells, macrophages, B cells, and microglia, not only in the draining lymph nodes but also striking

SUBMITTER: Kwiatkowski AJ 

PROVIDER: S-EPMC9618088 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature