Geometrically programmed self-limited assembly of tubules using DNA origami colloids.

ABSTRACT: Self-assembly is one of the most promising strategies for making functional materials at the nanoscale, yet new design principles for making self-limiting architectures, rather than spatially unlimited periodic lattice structures, are needed. To address this challenge, we explore the tradeoffs between addressable assembly and self-closing assembly of a specific class of self-limiting structures: cylindrical tubules. We make triangular subunits using DNA origami that have specific, valence-limited interactions and designed binding angles, and we study their assembly into tubules that have a self-limited width that is much larger than the size of an individual subunit. In the simplest case, the tubules are assembled from a single component by geometrically programming the dihedral angles bet

SUBMITTER: Hayakawa D 

PROVIDER: S-EPMC9618141 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature