DNA methylation alternation in Stanford- A acute aortic dissection.

ABSTRACT: Acute aortic dissection (AAD) is a life-threatening cardiovascular disease. Recent studies have shown that DNA methylation may be associated with the pathological mechanism of AAD, but the panorama of DNA methylation needs to be explored. DNA methylation patterns were screened using Infinium Human Methylation 450 K BeadChip in the aortic tissues from 4 patients with Stanford-A AAD and 4 controls. Gene enrichment was analyzed by Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway and gene ontology (GO). DNA methylation levels of candidate genes were determined by pyrosequencing in the replication cohort including 16 patients with AAD and 7 controls. Protein expression level of candidate gene was assessed by Western blot. A total of 589 differentially methylated positions including 315 hy

SUBMITTER: Chen Y 

PROVIDER: S-EPMC9618190 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature