Long-term cardiovascular outcomes of gestational diabetes mellitus: a prospective UK Biobank study.

ABSTRACT:

Background

Previous studies showed that gestational diabetes mellitus (GDM) can be a risk factor for subsequent atherosclerotic cardiovascular disease. However, there is a paucity of information regarding diverse cardiovascular outcomes in elderly women after GDM. In the current study, we examined whether women with a history of GDM have an increased risk for long-term overall cardiovascular outcomes.

Methods

Among the UK participants, we included 219,330 women aged 40 to 69 years who reported at least one live birth. The new incidence of diverse cardiovascular outcomes was compared according to GDM history by multivariable Cox proportional hazard models. In addition, causal mediation analysis was performed to examine the contribution of well-known risk factors to observed r

SUBMITTER: Lee SM 

PROVIDER: S-EPMC9618212 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature