Salicylic acid inducible nucleocytoplasmic shuttling of NPR1 fusion proteins in human cells.

ABSTRACT: Ligand inducible proteins that enable precise and reversible control of nuclear translocation of passenger proteins have broad applications ranging from genetic studies in mammals to therapeutics that target diseases such as cancer and diabetes. One of the drawbacks of the current translocation systems is that the ligands used to control nuclear localization are either toxic or prone to crosstalk with endogenous protein cascades within live animals. We sought to take advantage of salicylic acid (SA), a small molecule that has been extensively used in humans. In plants, SA functions as a hormone that can mediate immunity and is sensed by the nonexpressor of pathogenesis-related (NPR) proteins. Although it is well recognized that nuclear translocation of NPR1 is essential to promoting immuni

SUBMITTER: Sadeghi F 

PROVIDER: S-EPMC9618364 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature