Achyranthes aspera ameliorates stress induced depression in mice by regulating neuroinflammatory cytokines.

ABSTRACT:

Background and aim

Achyranthes aspera Linn. (A. aspera) (family: Amaranthaceae) is highly recognized in ethnomedicine and traditional systems of Indian medicine as a nervine restorative for several psychiatric disorders. Study presented here was designed to appraise the antidepressant-like effects of A. aspera in murine model of chronic unpredictable mild stress (CUMS) induced depression.

Experimental procedures-

Rodents were exposed to different stressor in unpredictive manner during CUMS protocol once a day for 4 weeks. Mice were intraperitoneally injected with A. aspera extract (2.5, 5 and 10 mg/kg) or fluoxetine (10 mg/kg) or betaine (20 mg/kg) once daily during day 15-28 of the CUMS protocol. Sucrose preference, motivation and self-care, immo

SUBMITTER: Gawande D 

PROVIDER: S-EPMC9618396 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature