Best genome sequencing strategies for annotation of complex immune gene families in wildlife.

ABSTRACT:

Background

The biodiversity crisis and increasing impact of wildlife disease on animal and human health provides impetus for studying immune genes in wildlife. Despite the recent boom in genomes for wildlife species, immune genes are poorly annotated in nonmodel species owing to their high level of polymorphism and complex genomic organisation. Our research over the past decade and a half on Tasmanian devils and koalas highlights the importance of genomics and accurate immune annotations to investigate disease in wildlife. Given this, we have increasingly been asked the minimum levels of genome quality required to effectively annotate immune genes in order to study immunogenetic diversity. Here we set out to answer this question by manually annotating immune genes in 5 marsupial ge

SUBMITTER: Peel E 

PROVIDER: S-EPMC9618407 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature