Retrosplenial and subicular inputs converge on superficially projecting layer V neurons of medial entorhinal cortex.

ABSTRACT: The medial entorhinal cortex (MEC) plays a pivotal role in spatial processing together with hippocampal formation. The retrosplenial cortex (RSC) is also implicated in this process, and it is thus relevant to understand how these structures interact. This requires precise knowledge of their connectivity. Projections from neurons in RSC synapse onto principal neurons in layer V of MEC and some of these neurons send axons into superficial layers of MEC. Layer V of MEC is also the main target for hippocampal efferents from the subiculum and CA1 field. The aim of this study was to assess whether the population of cells targeted by RSC projections also receives input from the hippocampal formation and to compare the distribution of synaptic contacts on target dendrites. We labeled the cells in

SUBMITTER: Simonsen OW 

PROVIDER: S-EPMC9618507 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature