Elevated inflammatory biomarkers and poor outcomes in intracerebral hemorrhage.

ABSTRACT:

Background

Accumulating evidence suggests that spontaneous intracerebral hemorrhage (ICH) is associated with a reactive neuroinflammatory response. However, it remains unclear if circulating inflammatory biomarkers are associated with adverse outcomes in ICH. To address this knowledge gap, we conducted a cohort study using a prospectively maintained stroke register in the United Kingdom to assess the prognostic value of admission inflammatory biomarkers in ICH.

Methods

The Norfolk and Norwich Stroke and TIA Register recorded consecutive ICH cases. The primary exposures of interest were elevation of white cell count (WCC; > 10 × 10⁹/L), elevation of c-reactive protein (CRP; > 10 mg/L), and co-elevation of both biomarkers, at the time of admission. Modified Poisson

SUBMITTER: Bader ER 

PROVIDER: S-EPMC9618534 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature