Identification of genes modified by N6-methyladenosine in patients with colorectal cancer recurrence.

ABSTRACT: Background: Recent studies demonstrate that N6-methyladenosine (m⁶A) methylation plays a crucial role in colorectal cancer (CRC). Therefore, we conducted a comprehensive analysis to assess the m⁶A modification patterns and identify m⁶A-modified genes in patients with CRC recurrence. Methods: The m⁶A modification patterns were comprehensively evaluated by the NMF algorithm based on the levels of 27 m⁶A regulators, and tumor microenvironment (TME) cell-infiltrating characteristics of these modification patterns were systematically assessed by ssGSEA and CIBERSORT algorithms. The principal component analysis algorithm based on the m⁶A scoring scheme was used to explore the m⁶A modification patterns of i

SUBMITTER: Zhu Q 

PROVIDER: S-EPMC9618605 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature