Identification of the immunosuppressive effect of γδ T cells correlated to bone morphogenetic protein 2 in acute myeloid leukemia.

ABSTRACT: Description of immune landscapes in malignant microenvironment is critical to the improvement of therapeutic strategies for various tumors. Acute myeloid leukemia (AML) remains a severe life-threatening malignancy and often confronts treatment dilemma in clinic. Although γδ T cells exhibit independent and potent cytotoxicity against leukemic cells in vitro and in the mouse models, efficacy of γδ T cell-based immunotherapy on AML patients has seemed unsatisfying so far. How the anti-AML capacity of γδ T cells is suppressed in vivo remains elusive. Herein, we found an aberrant γδ T cells subset expressing CD25⁺CD127^lowVδ2⁺ in the bone marrows of patients with newly diagnosed AML. The emergence of this subset was significantly associated with dis

SUBMITTER: Liang S 

PROVIDER: S-EPMC9618638 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature