Independent association of PCSK9 with platelet reactivity in subjects without statin or antiplatelet agents.

ABSTRACT:

Background and aims

Proprotein convertase subtilisin/kexin type 9 (PCSK9) levels could predict cardiovascular event in patients with well-controlled LDL-C levels, suggesting an LDL-independent mechanism of PCSK9 on the cardiovascular system. Accumulating evidence suggests PCSK9 might be associated with increased platelet reactivity. This study aimed to assess the relationship between PCSK9 levels and platelet reactivity in subjects not taking statins or antiplatelet agents.

Methods

A cross-sectional study was conducted to investigate the independent contribution of PCSK9 to platelet activity by controlling for the potential confounding factors. The study population included 89 subjects from a health examination centre who underwent routine annual health check-ups or had an e

SUBMITTER: Wang S 

PROVIDER: S-EPMC9618652 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature