Genome-wide association study for systemic lupus erythematosus in an egyptian population.

ABSTRACT: Systemic lupus erythematosus (SLE) susceptibility has a strong genetic component. Genome-wide association studies (GWAS) across trans-ancestral populations show both common and distinct genetic variants of susceptibility across European and Asian ancestries, while many other ethnic populations remain underexplored. We conducted the first SLE GWAS on Egyptians-an admixed North African/Middle Eastern population-using 537 patients and 883 controls. To identify novel susceptibility loci and replicate previously known loci, we performed imputation-based association analysis with 6,382,276 SNPs while accounting for individual admixture. We validated the association analysis using adaptive permutation tests (n = 10⁹). We identified a novel genome-wide significant locus near I

SUBMITTER: Elghzaly AA 

PROVIDER: S-EPMC9619055 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature