CT-derived vessel segmentation for analysis of post-radiation therapy changes in vasculature and perfusion.

ABSTRACT: Vessel segmentation in the lung is an ongoing challenge. While many methods have been able to successfully identify vessels in normal, healthy, lungs, these methods struggle in the presence of abnormalities. Following radiotherapy, these methods tend to identify regions of radiographic change due to post-radiation therapytoxicities as vasculature falsely. By combining texture analysis and existing vasculature and masking techniques, we have developed a novel vasculature segmentation workflow that improves specificity in irradiated lung while preserving the sensitivity of detection in the rest of the lung. Furthermore, radiation dose has been shown to cause vascular injury as well as reduce pulmonary function post-RT. This work shows the improvements our novel vascular segmentation method p

SUBMITTER: Wuschner AE 

PROVIDER: S-EPMC9619090 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature