Molecular subclusters of follicular lymphoma: a report from the United Kingdom's Haematological Malignancy Research Network.

ABSTRACT: Follicular lymphoma (FL) is morphologically and clinically diverse, with mutations in epigenetic regulators alongside t(14;18) identified as disease-initiating events. Identification of additional mutational entities confirms this cancer's heterogeneity, but whether mutational data can be resolved into mechanistically distinct subsets remains an open question. Targeted sequencing was applied to an unselected population-based FL cohort (n = 548) with full clinical follow-up (n = 538), which included 96 diffuse large B-cell lymphoma (DLBCL) transformations. We investigated whether molecular subclusters of FL can be identified and whether mutational data provide predictive information relating to transformation. DNA extracted from FL samples was sequenced with a 293-gene panel representing ge

SUBMITTER: Crouch S 

PROVIDER: S-EPMC9619185 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature