Serum proteomics screening intercellular adhesion molecule-2 improves intermediate-risk stratification in acute myeloid leukemia.

ABSTRACT:

Background

The clinical risk classification of acute myelocytic leukemia (AML) is largely based on cytogenetic and molecular genetic detection. However, the optimal treatment for intermediate-risk AML patients remains uncertain. Further refinement and improvement of prognostic stratification are therefore necessary.

Objectives

The aim of this study was to identify serum protein biomarkers to refine risk stratification in AML patients.

Design

This study is a retrospective study.

Methods

Label-free proteomics was used to identify the differential abundance of serum proteins in AML patients. Transcriptomic data were combined to identify key altered markers that could indicate the risk rank of AML patients. The survival status was assessed by Kaplan-Meier and multi

SUBMITTER: Zhang N 

PROVIDER: S-EPMC9619266 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature