Optokinetic set-point adaptation functions as an internal dynamic calibration mechanism for oculomotor disequilibrium.

ABSTRACT: Experience-dependent brain circuit plasticity underlies various sensorimotor learning and memory processes. Recently, a novel set-point adaptation mechanism was identified that accounts for the pronounced negative optokinetic afternystagmus (OKAN) following a sustained period of unidirectional optokinetic nystagmus (OKN) in larval zebrafish. To investigate the physiological significance of optokinetic set-point adaptation, animals in the current study were exposed to a direction-alternating optokinetic stimulation paradigm that better resembles their visual experience in nature. Our results reveal that not only was asymmetric alternating stimulation sufficient to induce the set-point adaptation and the resulting negative OKAN, but most strikingly, under symmetric alternating stimulation so

SUBMITTER: Lin TF 

PROVIDER: S-EPMC9619307 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature