Serum Transferrin Is an Independent Predictor of Mortality in Severe Alcoholic Hepatitis.

ABSTRACT:

Objectives

Severe alcoholic hepatitis (sAH) confers substantial mortality, but the disease course is difficult to predict. As iron parameters are attractive outcome predictors in other liver diseases, we tested their prognostic ability in sAH.

Methods

Serum ferritin, transferrin, iron, transferrin saturation, nontransferrin-bound iron, soluble transferrin receptor, and hepcidin were measured in 828 patients with sAH recruited prospectively through the STOPAH trial. The cohort was randomly divided into exploratory (n = 200) and validation sets (n = 628).

Results

Patients with sAH had diminished serum transferrin but increased transferrin saturation. Among iron parameters, baseline transferrin was the best predictor of 28-day (area under the receiver operated characteri

SUBMITTER: Atkinson SR 

PROVIDER: S-EPMC9619360 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature