Catalytic anti-oxidative stress for osteoarthritis treatment by few-layered phosphorene.

ABSTRACT: As one of the most common representations of articular cartilage damage, osteoarthritis (OA) is characterized by the apoptosis and dysfunction of chondrocytes as well as the progressive degradation of extracellular matrix, of which the main components are glycosaminoglycan and type Ⅱ collagen. Few-layered phosphorene (FLP) has been attracting great attentions in biomedical fields owing to the excellent capability of in-situ catalysis for scavenging oxidate-associated molecules, especially the reactive oxygen species (ROS) and reactive nitrogen species (RNS). Herein, FLP has been fabricated and employed for articular cartilage protection by means of deleting oxidate-associated molecules. The in vitro results show that as low as 200 ​μg/mL FLP is capable of diminishing oxidative damag

SUBMITTER: Zhang X 

PROVIDER: S-EPMC9619373 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature