Induction Chemotherapy in Low-Risk HPV+ Oropharyngeal Cancer.

ABSTRACT:

Opinion statement

Human papillomavirus (HPV) associated oropharyngeal squamous cell carcinoma (OPSCC) is rapidly increasing in incidence, and has now become the most common head and neck cancer (HNC). Studies have demonstrated that HPV associated OPSCC is associated with a favorable prognosis compared with its HPV-negative counterparts, yet standard multimodality therapy is often associated with substantial acute and late treatment-related toxicity. While locoregional control is improved in HPV+ OPSCC, distant metastasis rate has gained recognition as a major cause of death in this population, with some studies suggesting similar rates as non-HPV-related cancers. Induction chemotherapy has been of long-standing interest in locoregionally advanced HNC, yet its use in combination wit

SUBMITTER: Dolezal JM 

PROVIDER: S-EPMC9619415 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature