Neutralizing immunity induced against the Omicron BA.1 and BA.2 variants in vaccine breakthrough infections.

ABSTRACT:

Background

As of early 2022, the Omicron variants are the predominant circulating lineages globally. Understanding neutralizing antibody responses against Omicron BA.1 and BA.2 following vaccine breakthrough infections will provide insights into BA.2 infectivity and susceptibility to subsequent re-infection.

Methods

Live virus neutralization assays were used to study immunity against Delta and Omicron BA.1 and BA.2 variants in samples from 86 individuals, 24 unvaccinated (27.9%) and 63 vaccinated (72.1%), who were infected with Delta (n = 42, 48.8%) or BA.1 (n = 44, 51.2%). Among the 63 vaccinated individuals, 39 were unboosted (45.3%), while 23 were boosted (26.7%).

Results

In unvaccinated infections, neutralizing antibodies (nAbs) against the three variants were wea

SUBMITTER: Brazer N 

PROVIDER: S-EPMC9619439 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature