Remdesivir resistance in transplant recipients with persistent COVID-19.

ABSTRACT: New mutations conferring resistance to SARS-CoV-2 therapeutics have important clinical implications. We describe the first cases of an independently acquired V792I RNA-dependent RNA polymerase mutation developing in renal transplant recipients after remdesivir exposure. Our work underscores the need for augmented efforts to identify concerning mutations and address their clinical implications.

SUBMITTER: Hogan JI 

PROVIDER: S-EPMC9619446 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature