Duration of immune protection of SARS-CoV-2 natural infection against reinfection.

ABSTRACT:

Background

The future of the SARS-CoV-2 pandemic hinges on virus evolution and duration of immune protection of natural infection against reinfection. We investigated duration of protection afforded by natural infection, the effect of viral immune evasion on duration of protection, and protection against severe reinfection, in Qatar, between February 28, 2020 and June 5, 2022.

Methods

Three national, matched, retrospective cohort studies were conducted to compare incidence of SARS-CoV-2 infection and COVID-19 severity among unvaccinated persons with a documented SARS-CoV-2 primary infection, to incidence among those infection-naïve and unvaccinated. Associations were estimated using Cox proportional-hazard regression models.

Results

Effectiveness of pre-Omicron primar

SUBMITTER: Chemaitelly H 

PROVIDER: S-EPMC9619565 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature