Longitudinal SARS-CoV-2 Vaccine Antibody Responses and Identification of Vaccine Breakthrough Infections Among Healthcare Workers Using Nucleocapsid IgG.

ABSTRACT:

Background

Long-term studies of vaccine recipients are necessary to understand SARS-CoV-2 antibody durability, assess the impact of boosters on antibody levels, and protection from infection. The identification of vaccine breakthrough infections among fully vaccinated populations will be important in understanding vaccine efficacy and SARS-CoV-2 vaccine escape capacity.

Methods

SARS-CoV-2 Spike-RBD (S) and Nucleocapsid (N) IgG levels were measured in a longitudinal study of 1000 Chicago healthcare workers who were infection-naïve or previously-infected and then vaccinated. Changes in S and N IgG were followed up to 14 months and vaccine breakthrough infections were identified by increasing N IgG.

Results

SARS-CoV-2 S IgG antibody levels among previously infected and p

SUBMITTER: Anderson M 

PROVIDER: S-EPMC9619786 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature