Distinguishing SARS-CoV-2 persistence and reinfection: A retrospective cohort study.

ABSTRACT:

Background

SARS-CoV-2 reinfection is poorly understood, partly because few studies have systematically applied genomic analysis to distinguish reinfection from persistent RNA detection related to initial infection. We aimed to evaluate the characteristics of SARS-CoV-2 reinfection and persistent RNA detection using independent genomic, clinical, and laboratory assessments.

Methods

All individuals at a large academic medical center who underwent a SARS-CoV-2 nucleic acid amplification test (NAAT) ≥ 45 days after an initial positive test, with both tests between March 14th and December 30th, 2020, were analyzed for potential reinfection. Inclusion criteria required having ≥2 positive NAATs collected ≥45 days apart with a cycle threshold (Ct) value <35 at repeat testing. For ea

SUBMITTER: Turbett SE 

PROVIDER: S-EPMC9619827 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature