COVID-19 vaccination in systemic lupus erythematosus: a systematic review for effectiveness, immunogenicity, flares and acceptance.

ABSTRACT:

Aims

COVID-19 infection is associated with significant morbidity in systemic lupus erythematosus but is potentially preventable by vaccination, although the impact of the myriad vaccines among SLE patients is not established. We aimed to assess the effectiveness, efficacy, acceptance and safety of COVID-19 vaccination in SLE.

Methods

We performed a systematic review of PubMed, Embase, CENTRAL, WHO Clinical Trials and ClinicalTrials.gov publications until 8th June 2022 without language, publication year or publication status restrictions. Reports with fewer than 5 patients or incomplete information on study outcomes were excluded. Risk of bias was assessed, and results reported according to PRISMA 2020 guidelines.

Results

We identified 32 studies (34 reports) comprisin

SUBMITTER: Tan SYS 

PROVIDER: S-EPMC9620290 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature