Development and validation of seven phosphatidylethanol-homologues in dried blood spots including preliminary results after excessive use of an ethanol-based hand sanitizer.

ABSTRACT: Phosphatidylethanol (PEth) has become a widespread marker offering an up to four weeks retrospective window to detect alcohol use. Due to the COVID 19 pandemic, ethanol-based hand sanitizers are frequently used. The aim of this study was to develop and validate a method for determination of up to seven different homologues of PEth from dried blood spots (DBS) after use of an ethanol-based hand sanitizer. Objectives of its preliminary application were to prove whether a threshold of 20 ng/mL for PEth 16:0/18:1 is reached and whether other homologues are formed as well as if positive findings of urinary ethyl glucuronide (UEtG) can be observed with respect to assess monitoring of abstinence control programs. Ten volunteers (8 occasional, 2 regular drinkers) were recruited to excessively use

SUBMITTER: Herzog J 

PROVIDER: S-EPMC9620346 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature