Using follicular fluid metabolomics to investigate the association between air pollution and oocyte quality.

ABSTRACT:

Background and aim

Our objective was to use metabolomics in a toxicological-relevant target tissue to gain insight into the biological processes that may underlie the negative association between air pollution exposure and oocyte quality.

Methods

Our study included 125 women undergoing in vitro fertilization at an academic fertility center in Massachusetts, US (2005-2015). A follicular fluid sample was collected during oocyte retrieval and untargeted metabolic profiling was conducted using liquid chromatography with ultra-high-resolution mass spectrometry and two chromatography columns (C18 and HILIC). Daily exposure to nitrogen dioxide (NO₂), ozone, fine particulate matter, and black carbon was estimated at the women's residence using spatiotemporal models and av

SUBMITTER: Hwang S 

PROVIDER: S-EPMC9620437 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature