TMED9 Expression Level as a Biomarker of Epithelial Ovarian Cancer Progression and Prognosis.

ABSTRACT:

Background

Transmembrane emp24 domain-containing protein 9 (TMED9) belongs to the TMED/p24 family that transports, modifies, and packs proteins and lipids into vesicles for delivery to specific locations and is important in innate immune signaling via the endoplasmic reticulum-Golgi cargo pathway. TMED9 has been implicated in various cancer types; however, its role in epithelial ovarian cancer (EOC) is unclear. In this study, we aimed to elucidate the role and clinical significance of TMED9 in EOC.

Materials and methods

mRNA and protein levels of TMED9 and their associations with clinicopathological features in EOCs were evaluated using RNA-sequencing and immunohistochemistry data. Functional studies assessing the tumorigenic role of TMED9 in EOC cell lines were also perform

SUBMITTER: Han GH 

PROVIDER: S-EPMC9620446 | biostudies-literature | 2022 Nov-Dec

REPOSITORIES: biostudies-literature