Sex Hormone-regulated CMG2 Is Involved in Breast and Prostate Cancer Progression.

ABSTRACT:

Background/aim

Capillary morphogenesis gene 2 (CMG2) is involved in prostate and breast cancer progression. This study aimed to investigate sex hormone receptor-mediated regulation of CMG2 in breast and prostate cancer, and its implication in disease progression.

Materials and methods

Expression of CMG2, oestrogen receptor (ER) and androgen receptor (AR) was determined in breast and prostate cancer cell lines, respectively, using real-time quantitative PCR (QPCR) and western blot. Association between CMG2 and sex hormone receptors was analysed in a number of transcriptome datasets. Immunochemical staining was performed in tissue microarrays of breast cancer (BR1505D) and prostate cancer (PR8011A). CMG2 expression was determined in 17β-oestradiol treated breast cancer cells a

SUBMITTER: Fang Z 

PROVIDER: S-EPMC9620450 | biostudies-literature | 2022 Nov-Dec

REPOSITORIES: biostudies-literature