Annulated carbamates are precursors for the ring contraction of the adamantane framework.

ABSTRACT: We report a protocol for the one-pot two-step synthesis of noradamantane methylene amines. The first step is the triflic acid-promoted decarboxylation of adamantane carbamates, which causes rearrangement of the adamantane framework to form noradamantane iminium salts, which are reduced to amines in the second separate step.

SUBMITTER: Hrdina R 

PROVIDER: S-EPMC9620499 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature