One novel ACOT7-NPHP4 fusion gene identified in one patient with acute lymphoblastic leukemia: a case report.

ABSTRACT:

Background

Acute lymphoblastic leukemia (ALL) is a type of heterogeneous hematopoietic malignancy that accounts for approximately 20% of adult ALL. Although ALL complete remission (CR) rate has increased to 85-90% after induction chemotherapy, 40-50% of patients eventually relapsed. Therefore, it is necessary to improve the outcomes of ALL via accurate diagnosis and individualized treatments, which benefits in part from molecular biomarkers. Here, we identified a new fusion gene, Acyl-CoA Thioesterase 7-Nephrocystin 4 (ACOT7-NPHP4), in a 34-year-old patient with ALL. The fusion gene contributed to chemoresistance to doxorubicin and acted as a new molecular marker.

Case presentation

A 34-year-old male patient was diagnosed with ALL (common B cell) based on clinical manifestat

SUBMITTER: Zong X 

PROVIDER: S-EPMC9620589 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature