Sex differences exist in adult heart group 2 innate lymphoid cells.

ABSTRACT:

Background

Group 2 innate lymphoid cells (ILC2s) are the most dominant ILCs in heart tissue, and sex-related differences exist in mouse lung ILC2 phenotypes and functions; however, it is still unclear whether there are sex differences in heart ILC2s.

Results

Compared with age-matched wild-type (WT) male mice, 8-week-old but not 3-week-old WT female mice harbored an obviously greater percentage and number of heart ILC2s in homeostasis. However, the percentage of killer-cell lectin-like receptor G1 (Klrg1)^- ILC2s was higher, but the Klrg1⁺ ILC2s were lower in female mice than in male mice in both heart tissues of 3- and 8-week-old mice. Eight-week-old Rag2^-/- mice also showed sex differences similar to those of age-matched WT mice. Regarding su

SUBMITTER: Peng H 

PROVIDER: S-EPMC9620621 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature