CD44 is a prognostic biomarker and correlated with immune infiltrates in gastric cancer.

ABSTRACT:

Objective

Gastric carcinoma is the most common malignant tumour of the human digestive system worldwide. CD44 serves as a marker for several tumour stem cells, including gastric cancer. However, the prognostic value of CD44 and its correlation with immune infiltration in gastric cancer remain unclear.

Methods

The relative expression level of CD44 RNA in gastric cancer was analysed in the TCGA and GEPIA2 databases and validated in the GEO database. Differences in CD44 between gastric cancer cell lines and normal cells were detected by real-time PCR, and the HPA database was used to analyse the differential expression of CD44 protein in gastric cancer and normal tissues. The effect of CD44 on the proliferation and migration of gastric cancer cells was detected by CCK8 and tran

SUBMITTER: Hou W 

PROVIDER: S-EPMC9620622 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature