Association of triglyceride levels and prostate cancer: a Mendelian randomization study.

ABSTRACT:

Background

The association between triglyceride and prostate cancer (PCa) has been reported in observational studies. However, the causality from triglyceride on PCa remained unknown.

Method

Two-sample Mendelian randomization (MR) was performed with triglyceride genome-wide association study (GWAS) data from 177,861 individuals and GWAS summary statistics of PCa from 463,010 individuals. Then, 48 single nucleotide polymorphisms (SNPs) of triglyceride were used as instrumental variables (IVs) to conduct MR analysis on PCa. Inverse-variance weighted (IVW), Weighted median, MR-Egger regression, Simple mode and Weighted mode were used for MR analysis. To verify the sensitivity of the data, heterogeneity test, pleiotropy test and leave-one-out sensitivity test were performed.

SUBMITTER: Zhu S 

PROVIDER: S-EPMC9620626 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature