Drug-related adverse events potentially predict the efficacy of apatinib on advanced hepatocellular carcinoma.

ABSTRACT:

Background

Hepatocellular carcinoma (HCC) is the fourth leading cause of cancer-related deaths worldwide every year, and most HCC patients are diagnosed with advanced disease and can only receive systemic treatment. TKIs are the most important components of the systemic treatment of HCC and have both good efficacy and adverse events (AEs).  METHODS: This analysis included 207 patients with locally advanced unresectable or metastatic HCC who received oral treatment with apatinib. We analyzed the overall survival (OS) and progression-free survival (PFS) of patients with or without corresponding AEs to evaluate which AEs can predict the efficacy of apatinib.

Results

Patients with hand-foot syndrome (HFS; p = 0.005), proteinuria (p = 0.006) and diarrhea (p < 0.001) had significa

SUBMITTER: Gu X 

PROVIDER: S-EPMC9620633 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature