Artificial intelligence-derived neurofibrillary tangle burden is associated with antemortem cognitive impairment.

ABSTRACT: Tauopathies are a category of neurodegenerative diseases characterized by the presence of abnormal tau protein-containing neurofibrillary tangles (NFTs). NFTs are universally observed in aging, occurring with or without the concomitant accumulation of amyloid-beta peptide (Aβ) in plaques that typifies Alzheimer disease (AD), the most common tauopathy. Primary age-related tauopathy (PART) is an Aβ-independent process that affects the medial temporal lobe in both cognitively normal and impaired subjects. Determinants of symptomology in subjects with PART are poorly understood and require clinicopathologic correlation; however, classical approaches to staging tau pathology have limited quantitative reproducibility. As such, there is a critical need for unbiased methods to quantitatively analy

SUBMITTER: Marx GA 

PROVIDER: S-EPMC9620665 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature