MIF is a common genetic determinant of COVID-19 symptomatic infection and severity.

ABSTRACT:

Background

Genetic predisposition to coronavirus disease 2019 (COVID-19) may contribute to its morbidity and mortality. Because cytokines play an important role in multiple phases of infection, we examined whether commonly occurring, functional polymorphisms in macrophage migration inhibitory factor (MIF) are associated with COVID-19 infection or disease severity.

Aim

To determine associations of common functional polymorphisms in MIF with symptomatic COVID-19 or its severity.

Methods

This retrospective case-control study utilized 1171 patients with COVID-19 from three tertiary medical centers in the USA, Hungary and Spain, together with a group of 637 pre-pandemic, healthy control subjects. Functional MIF promoter alleles (-794 CATT5-8,rs5844572), serum MIF and solub

SUBMITTER: Shin JJ 

PROVIDER: S-EPMC9620729 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature