Physical inactivity links depressive symptoms and cognitive functioning among individuals with Parkinson's disease.

ABSTRACT:

Objective

Parkinson's disease (PD) is a neurodegenerative disorder caused by disruption of dopamine-producing cells. PD is associated with motor symptoms and nonmotor symptoms including depression and cognitive impairment. Past research suggests an association between depression and cognitive impairment in PD. Physical activity may have a therapeutic effect on both depression and cognitive impairment. The present study investigates if physical activity mediates the association between depressive symptoms and cognition in a longitudinal sample of individuals with PD.

Method

Participants include individuals newly diagnosed with PD (N = 487) enrolled in the Parkinson's Progression Marker Initiative (PPMI). Participants completed an array of neuropsychological tests over

SUBMITTER: Timblin H 

PROVIDER: S-EPMC9620779 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature